Engineering New Markets and Strong Businesses

3-V Biosciences
3-V Biosciences is discovering and developing novel therapeutics for the treatment of infectious diseases. The company’s innovative strategy targets host pathways required for infection, providing major advantages over traditional pathogen-directed therapies. 3-V Biosciences is initially focused on treating respiratory viral illnesses, and its strategy is readily applicable to other types of infections.
Menlo Park, CA

Arresto Biosciences
Arresto Biosciences Inc. is a clinical stage platform technology company that develops allosteric inhibitors of matrix enzymes that are involved in the pathogenesis of cancer, fibrosis and inflammatory diseases.  The lead clinical stage product is a monoclonal antibody which has shown efficacy in cancer and fibrosis models, including lung fibrosis.   The company is also developing allosteric inhibitors for the treatment of inflammatory and musculoskeletal diseases. Arresto’s medicines may offer treatment options to millions of patients worldwide suffering from grievous diseases.
Palo Alto, CA

Athena Neurosciences (acquired by Elan Corp)
Central nervous system therapeutics.
So. San Francisco, CA

Autonomic Technologies, Inc.
Medical devices to exploit the autonomic nervous system to alleviate pain and treat disease.
Redwood City, CA

BioCryst Pharmaceuticals
BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for influenza and lymphoma. In addition, the Company has a pre-clinical portfolio of novel compounds, directed against inflammation and autoimmune disease targets, to create long-term sustainable value.
Birmingham, AL

Biosite Diagnostics
Emergency room diagnostics.
San Diego, CA

Breathe Technologies
Breathe is the first provider of ultra lightweight, compact and portable respiratory systems with the potential to treat patients with chronic obstructive pulmonary disorders and sleep apnea.
San Ramon, CA

Cardima
Microcatheter solutions for electrophysiology.
Fremont, CA

CardioDx
CardioDx is a cardiovascular genomic diagnostics company located in Palo Alto, CA. CardioDx develops clinically validated genomic tests to aid clinicians in assessing and tailoring care of patients with cardiovascular disease, including coronary artery disease (CAD), cardiac arrhythmias, and heart failure.
Palo Alto, CA

Cardium Therapeutics, Inc.
Therapeutic products and devices for cardiovascular, ischemic and related indications.
San Diego, CA

Corixa
Therapeutic vaccines.
Seattle, WA

Corventis
Founded in 2005, Corventis, Inc. is developing wireless patient management solutions to address unmet clinical needs inherent in the treatment of high-risk patients across healthcare environments.
San Jose, CA

Crescendo Bioscience
Crescendo Bioscience is developing a broad range of quantitative, objective diagnostic tools to provide Rheumatologists with deeper clinical insights to more effectively manage patients with autoimmune and inflammatory diseases. The company is initially focused on rheumatoid arthritis.
South San Francisco, CA

eHealth Inc.
Online provider of health insurance.
Mountain View, CA

Epizyme
Epizyme is a biopharmaceutical company that is creating innovative drugs for major diseases based on important discoveries emerging from the field of epigenetics. The company has developed an enabling and integrated platform that is generating a robust and sustainable drug pipeline of first-in-class inhibitors of histone methyl transferases for targeted cancer therapy.
Cambridge, MA

Five Prime Therapeutics
Five Prime Therapeutics, Inc. is a clinical-stage, privately-held company discovering and developing innovative protein and antibody therapeutics. FivePrime is currently in Phase I with FP-1039 for solid tumors. Using its world-class biologics discovery platform, FivePrime is building a strong product pipeline in oncology, immunology and metabolic diseases. It has built a unique suite of technologies to mine selectively the entire extracellular human proteome - the complete collection of secreted proteins and receptors - for medically relevant therapeutic protein drugs. FivePrime is collaborating with Pfizer, Inc. in the fields of oncology and diabetes.
San Francisco, CA

Genentech
Developing novel medicines for serious and life-threatening diseases.
South San Francisco, CA

Genomic Health
Genomic Health (Nasdaq: GHDX) is a molecular-diagnostics company focused on the development and commercialization of genomic-based clinical laboratory services for cancer that allow physicians and patients to make individualized treatment decisions. The company currently markets the Oncotype DX breast cancer test® and the Oncotype DX colon cancer test®.
Redwood City, CA

Inspire Medical Systems
Inspire is developing and commercializing an innovative implantable neuromodulation system designed to treat Obstructive Sleep Apnea (OSA).
Minneapolis, MN

Intersect ENT
Intersect ENT Inc. is a medical device company pioneering novel therapies for Ear, Nose & Throat surgeons to utilize in providing improved treatment for their patients.
Palo Alto, CA

Align Technology
High technology orthodontic products.
Santa Clara, CA

Invuity
New technology in customized lighting and advanced visualization solutions for less invasive surgeries.
San Francisco, CA

iPierian
iPierian is a pioneering biopharmaceutical company that is taking the cutting-edge technologies of cellular reprogramming and directed differentiation to an entirely new level to harness the power of induced pluripotent stem cells to advance the understanding of human diseases and accelerate the discovery of more effective therapeutics for patients.
South San Francisco, CA

Juvaris BioTherapeutics Inc.
Juvaris BioTherapeutics, Inc. is developing novel, adjuvanted vaccines and immunotherapeutics to treat infectious disease and cancer.
Burlingame, CA.

Microcide
Anti-microbial drugs.
Mountain View, CA

Navigenics
Navigenics, Inc. specializes in personalized consumer health and wellness services, with the overall goal of improving health outcomes in individuals across the population. Navigenics educates and empowers consumers with knowledge of their genetic predispositions, and then motivates them to act on the information with support from their physician to prevent the onset of disease, achieve earlier diagnosis, appropriately manage disease or otherwise lessen its impact.
Redwood Shores, CA

Neurocrine Biosciences
Product-based biopharmaceutical company focused on neurological and endocrine-related diseases and disorders.
San Diego, CA

NeuroPace
Responsive neurostimulation for the treatment of epilepsy.
Mountain View, CA

Nexus Dx
Nexus Dx is a dynamic new clinical diagnostics company working to improve patient care by providing the medical community with rapid and reliable information at the Point of Care (POC). Initial products include both qualitative and quantitative cardiac assays.
San Diego, CA

Nodality
Nodality utilizes proprietary single cell based technology to characterize signaling pathways in cancer and autoimmune diseases to better link individual patients with appropriate therapies through both the development and commercialization of highly predictive clinical tests, and to reduce time, cost, and risks of drug development.
San Francisco, CA

Novavax, Inc.
Specialty biopharmaceuticals. Research, development and commercialization of proprietary products focused on drug delivery and biological technologies.
Malvern, PA

NuVasive, Inc.
Innovations-based medical device company focusing on the design, development & marketing of products for the surgical treatment of spine disorders.
San Diego, CA

Ophthonix, Inc.
High-resolution lenses for vision correction.
Vista, CA

Optimedica
A global ophthalmic company dedicated to working with ophthalmologists to evolve standards of care which provide significant benefits to both physicians and patients.
Santa Clara, CA

Orexigen
Orexigen is developing drugs for treatment of obesity.
La Jolla, CA

Pacific Biosciences
Commercializing a disruptive 3rd-Generation DNA sequencing system based on Single Molecule Real Time (SMRT) detection technology.
Menlo Park, CA

Pharmacopeia
Small molecule libraries.
Sunnyvale, CA

Pharmacyclics
Microcyclic chemistry.
Sunnyvale, CA

Pulmonx
Pulmonx Corporation is focused on developing and marketing minimally-invasive medical devices and technologies for the diagnosis and treatment of pulmonary disorders.
Redwood City, CA

Rapid Micro Biosystems
Rapid Micro Biosystems provides innovative products for automated and faster detection of microbial contamination in the manufacture of pharmaceutical, biotechnology, and personal care products.
Bedford, MA

RedBrick Health
RedBrick Health is a health technology company that helps organizations drive exceptional consumer health engagement and reductions in avoidable healthcare costs. The RedBrick Health platform blends highly personalized consumer experience, engaging social networking tools, and a unique rewards framework that links healthcare financing to healthy behaviors.
Minneapolis, MN

Spinal Modulation
Spinal Modulation is developing a next generation Spinal Cord Stimulation (SCS) technology to treat chronic back and lower extremity pain.
Redwood City, CA

Spiracur
Spiracur Inc. was founded to address the large and growing 2b+ wound care market. Their technology delivers negative pressure to wounds promoting tissue granulation and ultimately facilitating healing.
Sunnyvale, CA

Tethys Bioscience
Tethys is selling blood-based laboratory tests to determine an individual's risk for type 2 diabetes, permitting physicians to focus effective preemptive interventions on the subset of people who harbor most of the risk.
Emeryville, CA

TherOx
Developing a new treatment to reduce infarct size in heart attack patients.
Irvine, CA

TransMedics, Inc
TransMedics, Inc. is a leading medical device company dedicated to extending the life saving benefits of organ transplantation to patients suffering from end-stage organ failure.
Andover, MA

Trius Therapeutics
Trius Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for serious, life-threatening infections.
San Diego, CA

Veracyte
Veracyte is a molecular diagnostics company committed to reducing the high rate of inconclusive test results associated with fine needle aspirates (FNAs) and other cytology samples. The company’s first product is focused in thyroid cancer.
South San Francisco

Voyage Medical
Voyage is developing a high-resolution, direct visualization technology that will impact current intracardiac diagnostic and treatment techniques.
Redwood City, CA

Xcellerex, Inc.
Develops integrated, single-use systems for biopharmaceutical and vaccine manufacturing.
Marlborough, MA.

XDx, Inc.
Develops and markets molecular diagnostic tests for immune system measurement.
South San Francisco, CA